Thymosin Alpha-1 Peptide for Sale – Direct from Shanghai Manufacturer
Thymosin Alpha-1 (TA1) stands as one of the most extensively studied immunomodulatory peptides in modern biomedical research. This 28-amino acid peptide, derived from the thymus gland, plays a critical role in restoring and enhancing immune function, making it an invaluable research tool for scientists investigating immunology, infectious diseases, and vaccine development . If you are searching for “thymosin alpha-1 peptide for sale” for your laboratory investigations, you need a manufacturing partner who understands the complexity of this immunomodulatory peptide and can deliver the purity your studies demand. That partner is Apeptide (Shanghai) Co., Ltd.
We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase thymosin alpha-1 peptide for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller.
Understanding Thymosin Alpha-1: The Immunomodulatory Master Regulator
Thymosin Alpha-1 (TA1) is a synthetic 28-amino acid peptide (Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH) originally isolated from thymosin fraction 5 . It is the active component of thymosin fraction 5 and has been extensively studied for its ability to modulate and restore immune function .
Key Characteristics
| Parameter | Specification |
|---|---|
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | Approximately 3,108.4 g/mol |
| CAS Number | 62304-98-7 |
| Form | Lyophilized powder |
| Purity | ≥99% (verified by HPLC) |
| Storage | -20°C, protected from light and moisture |
Mechanism of Action
| Pathway | Mechanism | Research Implications |
|---|---|---|
| T-Cell Maturation | Promotes differentiation and maturation of T-lymphocytes | Immunology, T-cell development |
| Th1 Response | Shifts immune response toward Th1 (cellular immunity) | Vaccine adjuvants, infectious disease |
| Cytokine Modulation | Increases IL-2, IFN-γ, and IL-12; decreases IL-4 | Inflammation, immune regulation |
| NK Cell Activation | Enhances natural killer (NK) cell activity | Antitumor immunity, viral defense |
| Dendritic Cell Maturation | Promotes dendritic cell activation and antigen presentation | Vaccine development, immunotherapy |
| TLR Signaling | Activates Toll-like receptors (TLR2, TLR9) | Innate immunity, host defense |
Why Thymosin Alpha-1 Matters in Research
Thymosin Alpha-1 has been the subject of over 1,500 published studies and has been approved for clinical use in over 35 countries . Its potent immunomodulatory effects make it a critical research tool across multiple domains.
Key Research Applications
| Research Area | Key Findings | Research Context |
|---|---|---|
| Immunodeficiency | Restores immune function in immunocompromised models | HIV, primary immunodeficiencies |
| Infectious Diseases | Enhances resistance to viral, bacterial, and fungal infections | Influenza, hepatitis, COVID-19, sepsis |
| Vaccine Adjuvant | Enhances vaccine efficacy; increases antibody titers | Vaccine development, immunology |
| Cancer Immunology | Restores immune function in cancer models; enhances antitumor immunity | Immuno-oncology, checkpoint inhibitors |
| Autoimmune Disease | Modulates immune response; reduces inflammation | Autoimmunity, inflammatory disease |
| Aging Research | Reverses age-related immune decline (immunosenescence) | Gerontology, longevity studies |
Key Research Insights
| Finding | Significance |
|---|---|
| Vaccine Enhancement | TA1 significantly increases antibody responses to influenza and hepatitis B vaccines |
| COVID-19 Research | TA1 has been investigated for its potential to modulate immune response in viral infections |
| Cancer Immunotherapy | Restores T-cell function in immunosuppressed cancer patients; synergistic with checkpoint inhibitors |
| Th1 Polarization | Potent inducer of Th1-type immune responses (cellular immunity) |
The Critical Importance of Quality for Thymosin Alpha-1 Research
When you purchase thymosin alpha-1 peptide for sale, quality parameters are non-negotiable. TA1 is a 28-amino acid peptide with an N-terminal acetylation critical for biological activity .
The Apeptide Quality Standard
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99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)
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Mass Spectrometry: Molecular weight confirmation (3,108.4 Da expected)
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Amino Acid Analysis: Sequence verification of all 28 amino acids
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N-Terminal Acetylation Confirmation: Essential for biological activity
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Batch-Specific COAs: Full traceability with Certificates of Analysis
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Stability Testing: Ensuring integrity from our lab to yours
Why Purity Matters for Thymosin Alpha-1 Research
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Immune Cell Studies: Impurities can activate or suppress immune responses
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Cell Culture Applications: Endotoxin levels affect lymphocyte viability
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In Vivo Studies: Dosing consistency critical for immunomodulation studies
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Vaccine Adjuvant Studies: Impurities can confound immune response measurements
The Manufacturer Advantage: Why Source Thymosin Alpha-1 from Apeptide
When you search for “thymosin alpha-1 peptide for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice.
Complete Transparency
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Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.
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Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.
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No Middlemen: You pay manufacturer-direct pricing, not reseller markups.
Technical Expertise
Our team understands the specific requirements for thymosin alpha-1 research:
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Importance of N-terminal acetylation for biological activity
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Proper handling to maintain peptide stability
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Appropriate reconstitution for various assay systems
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Storage conditions to prevent degradation
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Documentation requirements for research compliance
Quality You Can Trust
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Rigorous Testing: Every batch undergoes HPLC and MS analysis
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Documentation: Full COAs provided for complete traceability
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Consistency: Reliable quality batch after batch
Seamless Supply to the USA Market
Sourcing thymosin alpha-1 peptide for sale from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.
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Fast Shipping: 5-7 business days to US addresses
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Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides
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Desiccant Protection: Double-sealed packaging to prevent moisture absorption
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Wholesale Programs: Dedicated support for small and large supply companies
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Customs Expertise: Smooth clearance with complete documentation
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Tracking Integration: Real-time visibility from Shanghai to your lab
Research Applications: Where Thymosin Alpha-1 Excels
Understanding the diverse applications of thymosin alpha-1 helps researchers appreciate why quality matters.
Immunology Research
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T-cell differentiation and maturation assays
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Th1/Th2 balance studies
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Cytokine profiling (IL-2, IFN-γ, IL-12, IL-4)
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NK cell activity assays
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Dendritic cell maturation and function
Infectious Disease Research
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Viral infection models (influenza, hepatitis, coronavirus)
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Bacterial infection models
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Sepsis and septic shock studies
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Antiviral immunity mechanisms
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Host-pathogen interactions
Vaccine Development
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Adjuvant efficacy studies
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Antibody titer measurements
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Cellular immune response assays
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Vaccine formulation optimization
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Immunogenicity enhancement
Cancer Immunology
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Immunosuppression reversal models
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Checkpoint inhibitor combination studies
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Antitumor T-cell responses
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Tumor microenvironment modulation
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Immunotherapy enhancement
Aging Research
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Immunosenescence models
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Age-related immune decline reversal
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Thymic function restoration
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Vaccine response in aged models
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Longevity and healthspan studies
Autoimmune Disease
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Inflammatory cytokine modulation
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Autoimmune disease models (EAE, colitis, arthritis)
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Immune regulation mechanisms
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Therapeutic intervention studies
Frequently Asked Questions
: What exactly is thymosin alpha-1 peptide for sale at Apeptide?
A: Thymosin Alpha-1 (TA1) is a synthetic 28-amino acid peptide derived from the thymus gland. It is a potent immunomodulatory peptide that enhances T-cell function, promotes Th1 immune responses, and activates natural killer cells. It is supplied strictly for laboratory investigation and in vitro research only, not for human consumption. thymosin alpha-1 peptide for sale
: What purity levels do you guarantee for thymosin alpha-1?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (3,108.4 Da expected), and batch-specific data.
: What is the CAS number for thymosin alpha-1?
A: The CAS number for thymosin alpha-1 is 62304-98-7 .
: What is the molecular weight of thymosin alpha-1?
A: The molecular weight is approximately 3,108.4 g/mol .
: What is the primary mechanism of thymosin alpha-1?
A: TA1 promotes T-cell differentiation and maturation, shifts immune response toward Th1 (cellular immunity), increases cytokine production (IL-2, IFN-γ), and activates natural killer cells and dendritic cells . thymosin alpha-1 peptide for sale
: What is the difference between thymosin alpha-1 and thymosin beta-4?
A: Thymosin alpha-1 is an immunomodulatory peptide that enhances T-cell function. Thymosin beta-4 is a separate peptide that binds actin and promotes cell migration and wound healing. They have distinct structures, mechanisms, and research applications.
: Is your thymosin alpha-1 for human consumption?
A: Absolutely not. Our thymosin alpha-1 is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals. All products are labeled “FOR RESEARCH USE ONLY.”
: How should I store thymosin alpha-1 upon receipt?
A: Thymosin alpha-1 should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture. Lyophilized powder is stable when stored properly. Avoid repeated freeze-thaw cycles.
: What solvent should I use for reconstitution?
A: For most research applications, sterile water, PBS (pH 7.4), or cell culture medium is appropriate. Thymosin alpha-1 is soluble in aqueous buffers. Contact our technical team for application-specific recommendations.
: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.
: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.
: What documentation do you provide for research compliance?
A: Every order includes batch-specific Certificates of Analysis (COAs) with HPLC and MS data. We also provide commercial invoices, packing lists, and customs documentation as needed.
Quality Control: The Apeptide Standard
Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.
Analytical Methods
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HPLC Analysis: Every batch tested for purity (typically 99%+)
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Mass Spectrometry: ESI-MS or MALDI-TOF for molecular weight confirmation (3,108.4 Da expected)
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Amino Acid Analysis: Sequence verification of all 28 amino acids
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N-Terminal Acetylation Confirmation: Essential for biological activity
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
-
Counterion Analysis: Acetate or TFA content specified
-
Water Content: ≤8.0% by Karl Fischer
-
Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Stability Studies: Ensuring integrity under various conditions
Batch Documentation
Each shipment includes:
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Certificate of Analysis with actual test results
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HPLC chromatogram (available upon request)
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Mass spectrometry data
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Batch number for traceability
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Expiration date and storage recommendations
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Reconstitution guidelines
Beyond Thymosin Alpha-1: A Complete Research Partner
Apeptide (Shanghai) Co., Ltd. is more than just a supplier of thymosin alpha-1 peptide for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide. thymosin alpha-1 peptide for sale
Our Capabilities
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Custom Synthesis: Develop proprietary peptides for your specific research needs
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Catalog Peptides: Hundreds of sequences available for immediate shipment
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Immunology Peptide Library: Including thymosin alpha-1, thymosin beta-4, and immunomodulatory peptides
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Fluorescent Dyes: High-purity labeling agents for imaging and detection
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Amino Acids: Building blocks for synthesis and research
Quality Certifications & Compliance
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Licensed manufacturer with physical facility in Pudong District, Shanghai
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Rigorous quality control protocols
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Transparent documentation and traceability
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Experienced technical support team
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Strict adherence to research-use-only compliance
The Science Behind Thymosin Alpha-1: A Master Regulator of Immunity
Thymosin Alpha-1 was first isolated from thymosin fraction 5 in the 1970s by Dr. Allan Goldstein and colleagues at the George Washington University . Its structure was elucidated as a 28-amino acid peptide with N-terminal acetylation, a modification essential for its biological activity .
The peptide’s mechanism of action involves multiple pathways:
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T-Cell Maturation: TA1 promotes the differentiation of immature T-cells into functional mature T-cells, increasing both CD4+ and CD8+ populations
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Th1 Polarization: Shifts the immune response toward Th1 (cellular immunity), increasing IL-2, IFN-γ, and IL-12 while decreasing Th2 cytokines like IL-4
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NK Cell Activation: Enhances natural killer cell activity, critical for antiviral and antitumor immunity
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Dendritic Cell Activation: Promotes dendritic cell maturation and antigen presentation
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TLR Signaling: Activates Toll-like receptors (TLR2 and TLR9), linking innate and adaptive immunity
Thymosin Alpha-1 has been approved for clinical use in over 35 countries for conditions including chronic hepatitis B, hepatitis C, and immunodeficiencies . In research settings, it continues to be studied for vaccine adjuvants, infectious disease, cancer immunotherapy, and immune restoration in aging . thymosin alpha-1 peptide for sale
The search for premium “thymosin alpha-1 peptide for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need thymosin alpha-1 for immunology research, vaccine development, infectious disease studies, or specialized immunotherapy applications, we are your trusted manufacturing partner. thymosin alpha-1 peptide for sale












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