MOTS-c 40mg

MOTS-c 40mg Peptide for Sale – Direct from Shanghai Manufacturer

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) represents a revolutionary class of signaling molecules in modern biomedical research. As a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome itself, MOTS-c has emerged as a critical tool for researchers investigating metabolic regulation, cellular stress response, aging, and mitochondrial-nuclear communication . If you are searching for “MOTS-c peptide for sale” for your laboratory investigations, you need a manufacturing partner who understands the significance of this 16-amino acid peptide and can deliver the purity your studies demand. That partner is Apeptide (Shanghai) Co., Ltd.

We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase MOTS-c peptide for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller. MOTS-c peptide for sale

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Understanding MOTS-c: The Mitochondrial-Encoded Signaling Peptide

MOTS-c is a 16-amino acid peptide encoded by the mitochondrial 12S rRNA region, making it unique among peptides as it originates from the mitochondrial genome rather than nuclear DNA . During metabolic stress—such as serum or glucose deprivation or oxidative stress—MOTS-c translocates to the nucleus in an AMPK-dependent manner, where it binds to the transcription factor NRF2 and activates anti-oxidative stress genes . MOTS-c peptide for sale

Key Characteristics

Mechanism of Action: The Metabolic Regulator

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Why MOTS-c Matters in Research

MOTS-c has been the subject of intensive investigation across multiple research domains. Its levels decrease with age in humans, suggesting a potential role in the aging process . A comprehensive 2025 review in Life Sciences systematically analyzed the associations of MOTS-c with T2DM risk factors and its protective potential in diabetic cardiomyopathy . MOTS-c peptide for sale

Key Research Applications

Potent Research-Grade Activity

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The Critical Importance of Quality for MOTS-c Research

When you purchase MOTS-c peptide for sale, quality parameters are non-negotiable. MOTS-c is a 16-amino acid peptide requiring precise synthesis to ensure correct sequence and full biological activity .MOTS-c peptide for sale

The Apeptide Quality Standard

• 99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)

• Mass Spectrometry: Molecular weight confirmation (2,174.6 Da expected)

• Amino Acid Analysis: Sequence verification (MRWQEMGYIFYPRKLR)

• Peptide Content Determination: Accurate net peptide weight (≥80% typical)

• Counterion Analysis: Acetate or TFA content specified

• Water Content: ≤8.0% by Karl Fischer

• Endotoxin Testing: <0.05 EU/mg available for cell culture applications

• Batch-Specific COAs: Full traceability with Certificates of Analysis

• Stability Testing: Stable for ≥1 year at -20°C

Why Purity Matters for MOTS-c Research

• AMPK Activation Assays: EC₅₀ values require precise dosing

• Metabolic Studies: Glucose uptake measurements are highly sensitive

• Cell Culture Applications: Endotoxin levels affect cellular metabolism

• In Vivo Studies: Dosing consistency critical for metabolic research

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The Manufacturer Advantage: Why Source MOTS-c from Apeptide

When you search for “MOTS-c peptide for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice. MOTS-c peptide for sale

Complete Transparency

• Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.

• Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.

• No Middlemen: You pay manufacturer-direct pricing, not reseller markups.

Technical Expertise

Our team understands the specific requirements for MOTS-c research:

• Importance of correct sequence for AMPK activation

• Proper handling to maintain peptide stability

• Appropriate reconstitution for metabolic assays

• Storage conditions to prevent degradation

• Documentation requirements for research compliance

Quality You Can Trust

• Rigorous Testing: Every batch undergoes HPLC and MS analysis

• Documentation: Full COAs provided for complete traceability

• Consistency: Reliable quality batch after batch

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Seamless Supply to the USA Market

Sourcing MOTS-c 40mg peptide from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.

• Fast Shipping: 5-7 business days to US addresses

• Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides

• Desiccant Protection: Double-sealed packaging to prevent moisture absorption

• Wholesale Programs: Dedicated support for small and large supply companies

• Customs Expertise: Smooth clearance with complete documentation

• Tracking Integration: Real-time visibility from Shanghai to your lab

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Research Applications: Where MOTS-c Excels

Understanding the diverse applications of MOTS-c helps researchers appreciate why quality matters. MOTS-c peptide for sale

Metabolic Disease Research

• Type 2 diabetes models (glucose homeostasis, insulin sensitivity)

• Obesity studies (energy expenditure, lipid metabolism)

• Diabetic cardiomyopathy (cardiac protection, metabolic regulation)

• Metabolic syndrome investigations

Mitochondrial Biology

• Mitochondrial-nuclear communication (retrograde signaling)

• Mitochondrial biogenesis (AMPK/PGC-1α pathway)

• Stress response (metabolic stress, oxidative stress)

• Cellular energetics and bioenergetics

Aging Research

• Age-related metabolic decline

• Lifespan studies in model organisms

• Healthspan and frailty assessments

• Age-associated mitochondrial dysfunction

Cardiovascular Research

• Diabetic cardiomyopathy

• Endothelial function

• Cardiac metabolism

• Ischemia-reperfusion injury

Neurobiology

• Neuroprotection (AMPK/PGC-1α pathway)

• Blood-brain barrier penetration studies

• Neurodegenerative disease models

• Cognitive function and synaptic plasticity

Inflammation Research

• NF-κB pathway inhibition

• Cytokine modulation (TNF-α, IL-6, IL-1β)

• Systemic inflammation models

• Immunometabolism

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Frequently Asked Questions

Q: What exactly is MOTS-c peptide for sale at Apeptide?
A: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial genome. It regulates metabolic homeostasis via AMPK activation and nuclear translocation. It is supplied strictly for laboratory investigation and in vitro research only, not for human consumption. MOTS-c peptide for sale

: What purity levels do you guarantee for MOTS-c?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (2,174.6 Da expected), and batch-specific data.

: What is the CAS number for MOTS-c?
A: The CAS number for MOTS-c is 1627580-64-6 .

: What is the molecular weight of MOTS-c?
A: The molecular weight is approximately 2,174.6 Da for the base peptide .

: What is the amino acid sequence of MOTS-c?
A: The sequence is H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH (MRWQEMGYIFYPRKLR) .

: What is the primary mechanism of MOTS-c?
A: MOTS-c activates AMPK, translocates to the nucleus during metabolic stress, binds NRF2, and activates anti-oxidative stress genes. It also inhibits the folate cycle and de novo purine synthesis .

: Does MOTS-c cross the blood-brain barrier?
A: Yes, research indicates that MOTS-c is a blood-brain barrier-penetrating peptide .

: Is your MOTS-c for human consumption?
A: Absolutely not. Our MOTS-c is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals. All products are labeled “FOR RESEARCH USE ONLY.”

: How should I store MOTS-c upon receipt?
A: MOTS-c should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture. It is stable for at least 1 year when stored properly at -20°C . Avoid repeated freeze-thaw cycles.

: What solvent should I use for reconstitution?
A: It is recommended to reconstitute lyophilized MOTS-c in sterile 18MΩ-cm H₂O at not less than 100 µg/ml, which can then be further diluted into other aqueous solutions . For long-term storage after reconstitution, adding a carrier protein (0.1% HSA or BSA) is recommended .

: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.

: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.  MOTS-c peptide for sale

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Quality Control: The Apeptide Standard

Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.

Analytical Methods

• HPLC Analysis: Every batch tested for purity (typically 99%+)

• Mass Spectrometry: ESI-MS or MALDI-TOF for molecular weight confirmation (2,174.6 Da expected)

• Amino Acid Analysis: Sequence verification (MRWQEMGYIFYPRKLR)

• Peptide Content Determination: Accurate net peptide weight (≥80% typical)

• Counterion Analysis: Acetate or TFA content specified

• Water Content: ≤8.0% by Karl Fischer

• Endotoxin Testing: <0.05 EU/mg available for cell culture applications

• Stability Studies: Ensuring integrity under various conditions

Batch Documentation

Each shipment includes:

• Certificate of Analysis with actual test results

• HPLC chromatogram (available upon request)

• Mass spectrometry data

• Batch number for traceability

• Expiration date and storage recommendations

• Reconstitution guidelines

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Beyond MOTS-c: A Complete Research Partner

Apeptide (Shanghai) Co., Ltd. is more than just a supplier of MOTS-c peptide for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide.

Our Capabilities

• Custom Synthesis: Develop proprietary peptides for your specific research needs

• Catalog Peptides: Hundreds of sequences available for immediate shipment

• Mitochondrial Peptide Library: Including MOTS-c, Humanin, SHLP1-6, and related peptides

• Fluorescent Dyes: High-purity labeling agents for imaging and detection

• Amino Acids: Building blocks for synthesis and research

Quality Certifications & Compliance

• Licensed manufacturer with physical facility in Pudong District, Shanghai

• Rigorous quality control protocols

• Transparent documentation and traceability

• Experienced technical support team

• Strict adherence to research-use-only compliance

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The Science Behind MOTS-c: A Mitochondrial-Encoded Metabolic Regulator

MOTS-c was discovered as part of a family of mitochondrial-derived peptides (MDPs) that also includes Humanin and SHLP1-6 . Unlike nuclear-encoded peptides, MOTS-c is encoded within the mitochondrial 12S rRNA region—a discovery that challenged the traditional view of mitochondrial function as solely energy production . MOTS-c peptide for sale

During metabolic stress—such as serum or glucose deprivation or oxidative stress—MOTS-c translocates to the nucleus in an AMPK-dependent manner, where it binds to the transcription factor NRF2 and activates anti-oxidative stress genes . This mechanism links mitochondrial stress directly to nuclear gene expression, establishing MOTS-c as a key mediator of mitochondrial-nuclear communication .

The peptide promotes biosynthesis of the endogenous AMP analog AICAR, leading to AMP-activated protein kinase (AMPK) activation . This induces cellular and systemic glucose uptake and improves insulin sensitivity . Preclinical studies have shown that MOTS-c prevents diet-induced obesity (DIO) in mice .

MOTS-c levels decrease with age in humans , and supplementation has been shown to extend lifespan in mice . A 2025 review in Life Sciences systematically analyzed the associations of MOTS-c with T2DM risk factors and its protective potential in diabetic cardiomyopathy . Another 2023 review in Frontiers in Endocrinology discussed the therapeutic exploitation of MOTS-c for aging, cardiovascular disease, insulin resistance, and inflammation .  MOTS-c peptide for sale

The search for premium “MOTS-c peptide for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need MOTS-c for metabolic disease research, aging studies, mitochondrial biology, or specialized investigations, we are your trusted manufacturing partner.  MOTS-c peptide for sale