CJC-1295 Without DAC Peptide for Sale – Direct from Shanghai Manufacturer
CJC-1295 without DAC (Drug Affinity Complex) represents a significant advancement in growth hormone research, offering scientists a potent and selective analog of growth hormone-releasing hormone (GHRH) with a well-defined pharmacokinetic profile . This 30-amino acid peptide was specifically designed to stimulate endogenous growth hormone (GH) secretion in a pulsatile manner, making it an indispensable research tool for scientists investigating the GH axis, pituitary function, and metabolic regulation . If you are searching for “CJC-1295 without DAC for sale” for your laboratory investigations, you need a manufacturing partner who understands the complexity of this GHRH analog and can deliver the purity your studies demand. That partner is Apeptide (Shanghai) Co., Ltd.
We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase CJC-1295 without DAC peptide from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller. CJC-1295 without DAC for sale
Understanding CJC-1295: The GHRH Analog
CJC-1295 is a synthetic 30-amino acid peptide analog of growth hormone-releasing hormone (GHRH). It was developed to overcome the short half-life of native GHRH through structural modifications that enhance stability while maintaining full biological activity . The “without DAC” version refers to the absence of the Drug Affinity Complex (DAC) modification, resulting in a shorter half-life that more closely mimics physiological pulsatile GH release .
Key Characteristics
| Parameter | Specification |
|---|---|
| Sequence | H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ (modified with 4-amino-3-(naphthalen-2-yl)butanoic acid substitution) |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Molecular Weight | Approximately 3,367.9 g/mol |
| CAS Number | 863288-34-0 |
| Form | Lyophilized powder |
| Purity | ≥99% (verified by HPLC) |
| Storage | -20°C, protected from light and moisture |
CJC-1295 With DAC vs. Without DAC: Key Differences
| Feature | CJC-1295 With DAC | CJC-1295 Without DAC |
|---|---|---|
| Half-Life | Extended (5-8 days) | Short (~30 minutes) |
| GH Release Pattern | Sustained, continuous | Pulsatile, physiological |
| DAC Modification | Present (Drug Affinity Complex) | Absent |
| Research Application | Continuous GH stimulation studies | Pulsatile GH secretion studies |
Why CJC-1295 Without DAC Matters in Research
CJC-1295 without DAC is designed to mimic the natural pulsatile secretion of growth hormone, which is essential for maintaining normal physiological function . Unlike continuous GH exposure, pulsatile stimulation preserves feedback mechanisms and prevents receptor desensitization . CJC-1295 without DAC for sale
Key Research Applications
| Research Area | Key Findings | Research Context |
|---|---|---|
| Growth Hormone Research | Potent GH stimulator; induces physiological pulsatile GH release | Endocrinology, pituitary function |
| GHRH Receptor Pharmacology | Selective GHRH receptor agonist; used to characterize receptor binding | Receptor pharmacology, drug development |
| Pulsatile GH Studies | Mimics natural GH pulsatility; preserves feedback mechanisms | Endocrine physiology, GH regulation |
| Aging Research | Counteracts age-related GH decline (somatopause) | Gerontology, age-related metabolic changes |
| Metabolic Research | Influences lipid metabolism and body composition | Obesity, metabolic regulation |
| Synergistic Studies | Works synergistically with GHRPs (e.g., ipamorelin, GHRP-2) | Combinatorial endocrinology |
Key Research Insights
| Finding | Significance |
|---|---|
| Pulsatile GH Release | Without DAC, the peptide stimulates GH in a pulsatile pattern that mimics natural secretion |
| Preserved Feedback | Short half-life prevents sustained GH elevation and negative feedback |
| Receptor Sensitivity | Maintains GHRH receptor sensitivity without desensitization |
| Physiological Action | More closely mimics endogenous GHRH activity |
The Critical Importance of Quality for CJC-1295 Research
When you purchase CJC-1295 without DAC for sale, quality parameters are non-negotiable. CJC-1295 is a 30-amino acid peptide with specific modifications requiring precise synthesis to ensure correct sequence, C-terminal amidation, and full biological activity . CJC-1295 without DAC for sale
The Apeptide Quality Standard
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99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)
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Mass Spectrometry: Molecular weight confirmation (3,367.9 g/mol expected)
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Amino Acid Analysis: Sequence verification of all 30 amino acids
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C-Terminal Amidation Confirmation: Essential for receptor binding and activity
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Batch-Specific COAs: Full traceability with Certificates of Analysis
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Stability Testing: Ensuring integrity from our lab to yours
Why Purity Matters for CJC-1295 Research
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Receptor Binding Studies: EC₅₀ values in nanomolar range require precise dosing
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In Vivo Studies: Dosing consistency critical for GH and IGF-1 measurements
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Cell Culture Applications: Impurities affect somatotroph viability
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Pulsatile Studies: Consistent material essential for pulse pattern studies
The Manufacturer Advantage: Why Source CJC-1295 from Apeptide
When you search for “CJC-1295 without DAC for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice.
Complete Transparency
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Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.
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Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.
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No Middlemen: You pay manufacturer-direct pricing, not reseller markups. CJC-1295 without DAC for sale
Technical Expertise
Our team understands the specific requirements for CJC-1295 research:
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Importance of C-terminal amidation for receptor binding
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Proper handling to maintain peptide stability
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Appropriate reconstitution for various assay systems
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Storage conditions to prevent degradation
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Documentation requirements for research compliance
Quality You Can Trust
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Rigorous Testing: Every batch undergoes HPLC and MS analysis
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Documentation: Full COAs provided for complete traceability
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Consistency: Reliable quality batch after batch
Seamless Supply to the USA Market
Sourcing CJC-1295 without DAC peptide from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.
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Fast Shipping: 5-7 business days to US addresses
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Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides
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Desiccant Protection: Double-sealed packaging to prevent moisture absorption
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Wholesale Programs: Dedicated support for small and large supply companies
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Customs Expertise: Smooth clearance with complete documentation
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Tracking Integration: Real-time visibility from Shanghai to your lab
Research Applications: Where CJC-1295 Without DAC Excels
Understanding the diverse applications of CJC-1295 without DAC helps researchers appreciate why quality matters.
Endocrinology Research
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GH pulsatility and regulation studies
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Pituitary somatotroph function
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GHRH receptor binding and signaling
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Feedback mechanisms (IGF-1, somatostatin)
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Pulsatile GH secretion patterns
Pulsatile GH Studies
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Physiological GH release modeling
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Pulsatility and metabolic effects
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Frequency and amplitude analysis
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Circadian rhythm interactions
Metabolic Research
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GH/IGF-1 axis and energy homeostasis
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Lipid metabolism and body composition
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Insulin sensitivity and glucose regulation
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Adipose tissue biology
Aging Research
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Somatopause models
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Age-related GH decline
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Frailty and sarcopenia studies
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Bone metabolism and osteoporosis
Combination Research
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Synergistic effects with GHRPs (ipamorelin, GHRP-2, GHRP-6)
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Pulsatile GH secretion enhancement
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Combinatorial endocrine signaling
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Amplified GH release studies
Frequently Asked Questions
: What exactly is CJC-1295 without DAC peptide for sale at Apeptide?
A: CJC-1295 without DAC is a synthetic 30-amino acid peptide analog of growth hormone-releasing hormone (GHRH). It stimulates endogenous growth hormone release in a pulsatile pattern that mimics natural secretion. It is supplied strictly for laboratory investigation and in vitro research only, not for human consumption. CJC-1295 without DAC for sale
: What purity levels do you guarantee for CJC-1295 without DAC?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (3,367.9 g/mol expected), and batch-specific data.
: What is the CAS number for CJC-1295 without DAC?
A: The CAS number for CJC-1295 is 863288-34-0 .
: What is the molecular weight of CJC-1295 without DAC?
A: The molecular weight is approximately 3,367.9 g/mol .
: What is the difference between CJC-1295 with DAC and without DAC?
A: CJC-1295 with DAC contains a Drug Affinity Complex (DAC) modification that extends half-life to 5-8 days, resulting in sustained GH release. Without DAC, the peptide has a short half-life (~30 minutes), producing pulsatile GH release that more closely mimics natural secretion . CJC-1295 without DAC for sale
: What is the primary mechanism of CJC-1295 without DAC?
A: CJC-1295 without DAC binds to GHRH receptors on pituitary somatotrophs, activating the cAMP signaling pathway and stimulating pulsatile growth hormone release. Its short half-life preserves physiological feedback mechanisms .
: Is your CJC-1295 for human consumption?
A: Absolutely not. Our CJC-1295 is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals. All products are labeled “FOR RESEARCH USE ONLY.”
: How should I store CJC-1295 upon receipt?
A: CJC-1295 should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture. Lyophilized powder is stable when stored properly. Avoid repeated freeze-thaw cycles.
: What solvent should I use for reconstitution?
A: For most research applications, sterile water, PBS (pH 7.4), or cell culture medium is appropriate. CJC-1295 is soluble in aqueous buffers. Contact our technical team for application-specific recommendations.
: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States.
: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.
: What documentation do you provide for research compliance?
A: Every order includes batch-specific Certificates of Analysis (COAs) with HPLC and MS data. We also provide commercial invoices, packing lists, and customs documentation as needed. CJC-1295 without DAC for sale
Quality Control: The Apeptide Standard
Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.
Analytical Methods
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HPLC Analysis: Every batch tested for purity (typically 99%+)
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Mass Spectrometry: ESI-MS or MALDI-TOF for molecular weight confirmation (3,367.9 Da expected)
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Amino Acid Analysis: Sequence verification of all 30 amino acids
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C-Terminal Amidation Confirmation: Essential for biological activity
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Stability Studies: Ensuring integrity under various conditions
Batch Documentation
Each shipment includes:
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Certificate of Analysis with actual test results
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HPLC chromatogram (available upon request)
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Mass spectrometry data
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Batch number for traceability
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Expiration date and storage recommendations
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Reconstitution guidelines
Beyond CJC-1295: A Complete Research Partner
Apeptide (Shanghai) Co., Ltd. is more than just a supplier of CJC-1295 without DAC for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide. CJC-1295 without DAC for sale
Our Capabilities
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Custom Synthesis: Develop proprietary peptides for your specific research needs
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Catalog Peptides: Hundreds of sequences available for immediate shipment
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Growth Hormone Research Library: Including GHRH analogs (CJC-1295, sermorelin), GHRPs (ipamorelin, GHRP-2, GHRP-6), and related peptides
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Fluorescent Dyes: High-purity labeling agents for imaging and detection
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Amino Acids: Building blocks for synthesis and research
Quality Certifications & Compliance
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Licensed manufacturer with physical facility in Pudong District, Shanghai
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Rigorous quality control protocols
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Transparent documentation and traceability
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Experienced technical support team
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Strict adherence to research-use-only compliance
The Science Behind CJC-1295 Without DAC: Pulsatile GH Stimulation
CJC-1295 was developed as a modified analog of GHRH to enhance stability while maintaining biological activity . The “without DAC” version lacks the Drug Affinity Complex modification, resulting in a short half-life (approximately 30 minutes) that produces pulsatile GH release—the physiological pattern essential for normal growth and metabolism .
The peptide’s structure includes specific modifications that:
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Enhance stability: Resists enzymatic degradation compared to native GHRH
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Maintain potency: Full GHRH receptor activation
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Enable pulsatility: Short half-life allows natural feedback mechanisms
Key research advantages of CJC-1295 without DAC:
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Physiological GH pulses: Mimics natural GH secretion patterns
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Preserved feedback: Prevents receptor desensitization
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Synergistic potential: Combines effectively with GHRPs for amplified GH release
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Well-characterized: Extensively studied in endocrinology research
This pulsatile profile makes CJC-1295 without DAC particularly valuable for:
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Studying physiological GH regulation
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Investigating the effects of GH pulsatility on metabolism
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Developing combination protocols with GHRPs
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Modeling age-related changes in GH secretion
The search for premium “CJC-1295 without DAC for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need CJC-1295 without DAC for pulsatile GH studies, growth hormone research, metabolic investigations, or specialized endocrine applications, we are your trusted manufacturing partner. CJC-1295 without DAC for sale











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