Premium HGH Fragment 176-191 Peptide for Sale – Direct from Shanghai Manufacturer
HGH Fragment 176-191 represents a significant advancement in growth hormone research, offering scientists a targeted tool for investigating lipolysis without the complex growth-promoting effects of full-length human growth hormone (hGH). This 16-amino acid peptide, corresponding to the C-terminal region of the hGH molecule, has been engineered to retain the lipid-mobilizing properties of growth hormone while eliminating its insulin-like and growth-promoting activities . If you are searching for “HGH fragment 176-191 for sale” for your laboratory investigations, you need a manufacturing partner who understands the specificity of this growth hormone fragment and can deliver the purity your studies demand. That partner is Apeptide (Shanghai) Co., Ltd.
We are a legitimate, licensed manufacturer operating from our headquarters at No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai, China. Our facility is dedicated to the research, development, and production of high-purity peptide raw materials, catalog peptides, fluorescent dyes, and amino acids. When you purchase HGH fragment 176-191 for sale from shanghaiapeptides.com, you are buying directly from the source—not a middleman or reseller. HGH fragment 176-191
Understanding HGH Fragment 176-191: The Targeted Lipolytic Peptide
HGH Fragment 176-191 is a synthetic 16-amino acid peptide corresponding to the C-terminal region of human growth hormone (hGH), specifically amino acids 176 through 191 . This fragment was discovered through research aimed at isolating the lipolytic (fat-burning) properties of growth hormone while separating them from the molecule’s growth-promoting and insulin-like effects . HGH fragment 176-191
Key Characteristics
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Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH (YLRIVQCRSVEGSCGF)
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Molecular Formula: C₇₈H₁₂₁N₂₃O₂₁S₂
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Molecular Weight: Approximately 1,721.5 g/mol
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CAS Number: 129204-83-5
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Form: Lyophilized powder
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Purity: ≥99% (verified by HPLC)
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Storage: -20°C, protected from light and moisture
Mechanism of Action
HGH Fragment 176-191 exerts its effects through a distinct mechanism separate from full-length hGH:
| Pathway | Mechanism | Research Implications |
|---|---|---|
| Lipolysis Activation | Stimulates fat breakdown in adipocytes via specific receptor interactions | Investigates adipose tissue metabolism and lipid mobilization |
| No IGF-1 Activity | Does not stimulate insulin-like growth factor-1 (IGF-1) production | Allows isolated study of lipolytic effects without growth pathway activation |
| No Insulin-Like Activity | Lacks the insulin-mimetic effects of full-length hGH | Eliminates confounding effects on glucose metabolism |
| Adipose Tissue Specificity | Shows preferential activity on white adipose tissue | Studies regional fat distribution and adipocyte biology |
| β-Adrenergic Modulation | May enhance β-adrenergic receptor sensitivity | Investigates sympathetic nervous system interactions |
Why HGH Fragment 176-191 Matters in Research
HGH Fragment 176-191 was developed following the discovery that the lipolytic activity of growth hormone resides in the C-terminal region of the molecule, distinct from its growth-promoting domain . This structural separation has made it an invaluable tool for researchers studying adipose tissue metabolism without the confounding effects of growth hormone’s other activities.
Key Research Applications
Scientists seek HGH fragment 176-191 for sale for various laboratory investigations:
| Research Area | Key Findings | Research Context |
|---|---|---|
| Adipose Tissue Metabolism | Stimulates lipolysis in white adipose tissue; reduces fat accumulation | Adipocyte biology, lipid metabolism |
| Obesity Research | Reduces body fat in animal models without affecting muscle mass | Metabolic disease models, body composition |
| Lipid Metabolism | Enhances fatty acid oxidation; reduces triglyceride storage | Lipid homeostasis, metabolic regulation |
| Insulin Sensitivity | Does not affect insulin sensitivity (unlike full-length hGH) | Diabetes research, glucose metabolism |
| Regional Fat Distribution | May preferentially affect visceral adiposity | Metabolic syndrome, cardiovascular risk |
| Comparative Endocrinology | Species-specific sensitivity studies | Evolutionary biology, receptor pharmacology |
Distinctive Features
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No Growth-Promoting Activity: Does not stimulate linear growth or organomegaly
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No IGF-1 Stimulation: Does not elevate IGF-1 levels, avoiding downstream signaling
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No Insulin Resistance: Lacks the insulin-antagonistic effects of full-length hGH
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Lipolytic Specificity: Targeted effects on adipose tissue lipid metabolism
The Critical Importance of Quality for HGH Fragment Research
When you purchase HGH fragment 176-191 for sale, quality parameters are non-negotiable. This peptide contains two cysteine residues that can form disulfide bridges, requiring precise synthesis to ensure correct folding and full biological activity.
The Apeptide Quality Standard
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99% Purity Guarantee: Verified by High-Performance Liquid Chromatography (HPLC)
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Mass Spectrometry: Molecular weight confirmation (1,721.5 Da expected)
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Amino Acid Analysis: Sequence verification of all 16 amino acids
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Disulfide Bridge Confirmation: Ensuring correct cysteine connectivity
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Batch-Specific COAs: Full traceability with Certificates of Analysis
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Stability Testing: Ensuring integrity from our lab to yours
Why Purity Matters for HGH Fragment Research
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Lipolysis Assays: Fatty acid release measurements are highly sensitive to impurities
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Adipocyte Culture: Impurities can affect cell viability and function
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In Vivo Studies: Dosing consistency critical for metabolic research
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Mechanistic Studies: Pathway analysis demands documented purity
The Manufacturer Advantage: Why Source HGH Fragment from Apeptide
When you search for “HGH fragment 176-191 for sale,” you encounter many options. Here is why direct sourcing from our Shanghai facility is the superior choice.
Complete Transparency
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Physical Location: We operate from No. B Room 326, Jinhai Road 2588, Pudong District, Shanghai. You can verify our credentials.
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Manufacturing Expertise: Decades of combined experience in peptide synthesis and biochemical production.
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No Middlemen: You pay manufacturer-direct pricing, not reseller markups.
Technical Expertise
Our team understands the specific requirements for HGH fragment research:
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Importance of disulfide bridge formation for biological activity
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Proper handling to maintain peptide stability
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Appropriate reconstitution for various assay systems
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Storage conditions to prevent degradation
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Documentation requirements for research compliance
Quality You Can Trust
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Rigorous Testing: Every batch undergoes HPLC and MS analysis
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Documentation: Full COAs provided for complete traceability
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Consistency: Reliable quality batch after batch
Seamless Supply to the USA Market
Sourcing HGH fragment 176-191 for sale from China should be straightforward. We have optimized our logistics specifically for American researchers and wholesale partners.
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Fast Shipping: 5-7 business days to US addresses
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Cold-Chain Packaging: Temperature-controlled transit at -20°C for sensitive peptides
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Desiccant Protection: Double-sealed packaging to prevent moisture absorption
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Wholesale Programs: Dedicated support for small and large supply companies
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Customs Expertise: Smooth clearance with complete documentation
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Discreet Packaging: Professional, temperature-controlled containers
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Tracking Integration: Real-time visibility from Shanghai to your lab
Research Applications: Where HGH Fragment 176-191 Excels
Understanding the diverse applications of HGH Fragment 176-191 helps researchers appreciate why quality matters. HGH fragment 176-191
Adipose Tissue Biology
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White adipose tissue (WAT) lipolysis
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Adipocyte differentiation and metabolism
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Fat oxidation pathways
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Adipose tissue browning research
Metabolic Research
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Lipid metabolism and fatty acid oxidation
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Triglyceride storage and mobilization
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Energy homeostasis
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Metabolic rate studies
Obesity Research
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Diet-induced obesity (DIO) models
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Body composition analysis
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Visceral fat reduction
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Weight regulation mechanisms
Diabetes Research
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Insulin sensitivity studies (non-interference)
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Glucose homeostasis
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Metabolic syndrome models
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Pancreatic beta cell function
Receptor Pharmacology
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Growth hormone receptor interactions (fragment-specific)
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Adipocyte receptor binding studies
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Species-specific sensitivity
Comparative Endocrinology
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Evolutionary conservation of lipolytic activity
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Cross-species receptor specificity
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Growth hormone evolution studies
Frequently Asked Questions
: What exactly is HGH fragment 176-191 peptide for sale at Apeptide?
A: HGH Fragment 176-191 is a synthetic 16-amino acid peptide corresponding to the C-terminal region of human growth hormone (amino acids 176-191). It retains the lipolytic (fat-burning) properties of full-length hGH but lacks its growth-promoting and insulin-like effects . It is supplied strictly for laboratory investigation and in vitro research only, not for human consumption. Our HGH Fragment is manufactured at our Shanghai facility with 99% purity verification. HGH fragment 176-191
: What purity levels do you guarantee for HGH Fragment 176-191?
A: We guarantee 99% purity, verified by HPLC testing with Certificates of Analysis available for every batch. Each COA provides detailed purity analysis, mass spectrometry confirmation (1,721.5 Da expected), and batch-specific data.
: What is the CAS number for HGH Fragment 176-191?
A: The CAS number for HGH Fragment 176-191 is 129204-83-5 .
: What is the molecular weight of HGH Fragment 176-191?
A: The molecular weight is approximately 1,721.5 g/mol .
: How does HGH Fragment 176-191 differ from full-length human growth hormone?
A: Full-length hGH has multiple biological activities including lipolysis, insulin-like effects, growth promotion, and IGF-1 stimulation. HGH Fragment 176-191 retains only the lipolytic activity, allowing researchers to study fat metabolism without the confounding effects of growth hormone’s other activities .
: Does HGH Fragment 176-191 stimulate IGF-1 production?
A: No. Unlike full-length hGH, HGH Fragment 176-191 does not stimulate insulin-like growth factor-1 (IGF-1) production, eliminating downstream growth factor signaling .
: Is your HGH Fragment 176-191 for human consumption?
A: Absolutely not. Our HGH Fragment 176-191 is strictly for research and laboratory use only. It is not for human consumption, clinical application, or any use involving humans or animals. All products are labeled “FOR RESEARCH USE ONLY.”
: How should I store HGH Fragment 176-191 upon receipt?
A: HGH Fragment 176-191 should be stored at -20°C (freezer) immediately upon receipt, protected from light and moisture. Lyophilized powder is stable when stored properly. Avoid repeated freeze-thaw cycles.
: What solvent should I use for reconstitution?
A: For most research applications, sterile water, PBS (pH 7.4), or cell culture medium is appropriate. HGH Fragment 176-191 is soluble in aqueous buffers. Contact our technical team for application-specific recommendations.
: Do you ship to all 50 US states?
A: Yes. We ship to research institutions, laboratories, and wholesale partners throughout the United States. HGH fragment 176-191
: Can you accommodate bulk orders for wholesale distribution?
A: Absolutely. We offer competitive wholesale pricing for qualified partners. Contact our team through shanghaiapeptides.com with your volume requirements.
: What documentation do you provide for research compliance?
A: Every order includes batch-specific Certificates of Analysis (COAs) with HPLC and MS data. We also provide commercial invoices, packing lists, and customs documentation as needed.
Quality Control: The Apeptide Standard
Your research deserves nothing less than the highest purity materials. Our quality control protocols exceed industry standards.
Analytical Methods
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HPLC Analysis: Every batch tested for purity (typically 99%+)
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Mass Spectrometry: ESI-MS or MALDI-TOF for molecular weight confirmation (1,721.5 Da expected)
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Amino Acid Analysis: Sequence verification of all 16 amino acids
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Disulfide Bridge Confirmation: Ensuring correct cysteine connectivity
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Peptide Content Determination: Accurate net peptide weight (≥80% typical)
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Counterion Analysis: Acetate or TFA content specified
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Water Content: ≤8.0% by Karl Fischer
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Endotoxin Testing: <0.05 EU/mg available for cell culture applications
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Stability Studies: Ensuring integrity under various conditions
Batch Documentation
Each shipment includes:
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Certificate of Analysis with actual test results
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HPLC chromatogram (available upon request)
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Mass spectrometry data
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Batch number for traceability
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Expiration date and storage recommendations
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Reconstitution guidelines
Beyond HGH Fragment 176-191: A Complete Research Partner
Apeptide (Shanghai) Co., Ltd. is more than just a supplier of HGH fragment 176-191 for sale. We are a full-service biochemical manufacturer committed to advancing research worldwide.
Our Capabilities
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Custom Synthesis: Develop proprietary peptides for your specific research needs
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Catalog Peptides: Hundreds of sequences available for immediate shipment
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Growth Hormone Fragment Library: Including AOD9604, HGH Fragment 176-191, and related peptides
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Fluorescent Dyes: High-purity labeling agents for imaging and detection
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Amino Acids: Building blocks for synthesis and research
Quality Certifications and Compliance
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Licensed manufacturer with physical facility in Pudong District, Shanghai
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Rigorous quality control protocols
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Transparent documentation and traceability
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Experienced technical support team
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Strict adherence to research-use-only compliance
The Science Behind HGH Fragment 176-191
The discovery that the lipolytic activity of human growth hormone resides in its C-terminal region was a significant breakthrough in endocrinology research. Full-length hGH has multiple biological effects mediated through different domains of the molecule . The N-terminal region is associated with growth-promoting and insulin-like activities, while the C-terminal region (amino acids 177-191) is responsible for lipid-mobilizing effects .
HGH Fragment 176-191 was developed to isolate these lipolytic properties. Research has demonstrated that this fragment: HGH fragment 176-191
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Stimulates lipolysis in isolated adipocytes
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Reduces fat accumulation in animal models
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Does not affect linear growth or organ size
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Does not alter insulin sensitivity
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Does not stimulate IGF-1 production
These properties make HGH Fragment 176-191 a valuable research tool for investigating adipose tissue metabolism independent of the complex effects of full-length growth hormone.
The search for premium “HGH fragment 176-191 for sale” ends at Apeptide (Shanghai) Co., Ltd. As a dedicated manufacturer of peptides and biochemicals, we combine scientific expertise with manufacturing integrity to deliver the purest research materials available. Whether you need HGH Fragment 176-191 for adipose tissue research, obesity studies, or specialized metabolic investigations, we are your trusted manufacturing partner. HGH fragment 176-191











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